IL-13 regulates cilia loss and foxj1 expression in human airway epithelium.
mucociliary clearance is essential to the defense mechanism of the respiratory system. Loss of normal mucociliary clearance contribute to the pathogenesis of lung disease genetic and acquired. Care network differentiated human airway epithelial cultured Equine Clia Kits with IL-13 resulted in the loss of ciliated epithelial cells and increased mucus-secreting cells. The loss of ciliated cells characterized by basal body mislocation Ezrin and loss of apical cell compartment. In addition to the loss of ciliated cells and mucous cells increased after IL-13 treatment, the cells with the characteristics of both ciliated cells, and mucosal epithelium were observed in the airways. In relation to the decrease in ciliated cells after IL-13 treatment, there was recorded a decrease foxj1 expression in airway epithelium, characterized by a decrease in the number of foxj1-expressing cells. In foxj1 promoter, STAT-binding element is identified and inhibition of expression foxj1 by S...